Cardiac Cycle

Learning Objectives

·         Introduction
·         Definition
·         Events
o   Electrical
o   Mechanical
§  Atrial Systole
§  Atrial Diastole
§  Ventricular Systole
§  Ventricular Diastole
o   Hemodynamic
§  Pressure changes
§  Volume changes
o   Acoustic events
§  Heart sounds

Introduction

·         Heart
o   is a double pump, i.e. it consists of 2 separate pumps connected in series
o   Right heart pumps blood through lungs
o   Left heart pumps blood through peripheral organs
·         Right heart
o   Right atrium
o   Right ventricle
·         Left heart
o   Left atrium
o   Left ventricle

·         Atrium – Primary pumps for ventricles
·         Ventricles  - Pumps blood through pulmonary and systemic circulation
·         Systole – contraction phase
·         Diastole – relaxation phase
·         Autorhythmicity – Pacemaker – SA Node

Definition

·         The sequential cardiac events that occur from the beginning of one heart beat to the beginning of the next
·         Duration – 0.8 sec  (HR = 75)

Events

·         Electrical
·         Mechanical
·         Hemodynamic
·         Acoustic

Phases of Cardiac cycle

·         Two cycles
o   Atrial Cycle
§  Atrial contraction / systole (0.1 s)
§  Atrial relaxation /diastole (0.7 s)
o   Ventricular Cycle
§  Venticular contraction / systole (0.3 s)
§  Ventricular relaxation / diastole (0.5 s)

Pressure and Volume changes

Significant changes during events of cardiac cycle are
      Pressure changes
     Atrial pressure changes
     Ventricular pressure changes
     Aortic pressure changes
      Volume changes
     Ventricular volume changes

Atrial systole
Atrial depolarization
Atrial contraction
Atrial pressure rises

Blood flows across AV valves

Body water and Body fluids Blood volume

Learning objectives

  • Body fluid compartments
  • Composition and significance of body fluid compartments
  • Measurement of Body fluids
  • Water and electrolyte balance
  • Blood volume
  • Disorders of fluid volume

Introduction

“Homeostasis”
Physiological mechanisms which act to stabilize the internal environment.

“Mileu interieur”
The extracellular fluid is the internal environment of the body


Body composition
  • Average adult male with 70kg body weight
  • Water (60%)
  • Minerals (7%)
  • Protein and related substances (18%)
  • Fat (15%)
  • Water:- total body water with electrolytes
Total body water(TBW)
  • Water constitutes about 60% of body weight.
  • 50% in females
  • Greater amount of fat tissue.
  • This percentage can change, depending on age, gender, and degree of obesity.
  • As a person grows older, the percentage of total body weight that is fluid gradually decreases.


White Blood Cells - WBCs


  • White blood cells / Leucocytes, Leuco = white
  • Role – defence mechanism/protection

Difference between WBC & RBC


Classification of WBCs

Morphology of WBCs

Neutrophils

  1. Also called Polymorphs
  2. Contain fine/small granules in cytoplasm
  3. Take both acidic & basic stain
  4. Granules appear violet with Leishman’s stain
  5. No. of  lobes represents age of the cell
  6. Diameter – 10 to 12 ยต
  7. Shows amoeboid movement

Search this Site